These 45 mm non-reactive. autoclavabte caps have sure-grips for easy handing, Use these caps with the Wheaton Lab 45" media bottles or whit other media bottles having a 45 mm screw thread finish. Caps with the inner sealing ring provide a leak-resistant seal. Caps without the sealing ring can be used with the 224100-503 stopper for lyophillization applications. The liner in in the Teflon® faced silicone lined cap is ultrasonically bonded to eliminate toxicity and to ensure product safety The cap with the open top can be accessible with a syringe and can also be used with a 43 mm stopper Use the snap-on pour ring with Polypropylene caps to eliminate dripping of bottle contents while pouring. The ring is manufactured from autoclavable non-reactive Polypropylene and is easily snapped onto any Lab 45" media bottle with a pour lip.